The article describes the history of the study of the Stone Age in Northern Uzbekistan. From the second half of the twentieth century until the independence of our country, this region has always attracted special attention of scientists. Today it is known that from the end of the 20th century to the beginning of the 90s. more than 10 monuments of the Paleolithic time were discovered, such as the sites of Esen-2, Karakuduk, Shakhpakty, etc. As a result of the work carried out, over the course of dozens of years, the first monuments of the Paleolithic time of Northern Uzbekistan, recognized by experts of a wide range, were discovered, exploration work was carried out, as a result of which a good collection of stone products dated to the Paleolithic was collected, and the first measures were taken to interpret these finds. Including all the described Paleolithic sites of Northern Uzbekistan, as well as selected stone artifacts from sites, show the consistent development of the Paleolithic culture in Ustyurt, from the Mousterian era to the end of the Pleistocene and the beginning of the Holocene. It is quite logical that the stone industry of the above listed monuments reveals a great similarity with the monuments that were discovered in modern times and require a new rethinking.