Hazarah tribe composed of Turk and Moghul peoples. First contact between Hazarah tribe and Safavid state started in the first half of 16th century. Southern Khorasan was seized by Babur Shah when Timurid State fell down. In this period Hazarahs who were residents of Southern Khorasan and depended to Babur consist of two groups as Sunni and Shii. Shahs of Safavid repeatedly attacked to Southern Khorasan since the sovereignty of Shah Tahmasb I. There are two main reasons of these attacks. Firstly, the good relations between Safavid and Babur deteriorated secondly these two states were competing with each other. Finally, both Shah Tahmasb I and Shah Abbas I seized Kandahar. However, Hazarahs were most affected by these conflicts. These attacks caused that some of Hazarah tribes accepted administration of Safavid State. Moreover, Hazarahs, in crowd groups, converted to Shia sect from Sunni sect with influence of Shiite Safavid. In this paper will be discussed Hazarahs in Iran domination and their new political and social structure as have been benefited from Safavid chronicles.